Matthew Zachary
- 30-Year Brain Cancer Survivor
- Author, We the Patients (Wiley)
- Host, Healthcare’s #1 Independent Podcast
- Unfiltered Voice of Reason
Matthew Zachary Speaker Biography
Matthew Zachary has spent three decades making American healthcare less cruel. A 30-year brain cancer survivor, he founded Stupid Cancer, the largest nonprofit for young adults with cancer, and launched The Stupid Cancer Show, widely regarded as the first healthcare podcast, which evolved into the award-winning Out of Patients. He produced The Cancer Mavericks, a documentary series about the rebel patients who changed modern oncology. He is the author of We the Patients: Understanding, Navigating, and Surviving America’s Healthcare Nightmare (Wiley, 2026) and the founder of We the Patients, a national movement organizing patients into collective civic power. A concert pianist who has performed for audiences of thirty thousand, he has been featured in The New York Times, The Washington Post, People, Time, and The Atlantic. He is healthcare’s most inconvenient truth teller.
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Speech Topics
Get Busy Living: Surviving Brain 30 Years Ago and Living To Tell the Tale
The Talk
The personal origin story. Brain cancer at 21. A campus doctor who prescribed Robitussin.
A golf ball sized tumor. The loss of a piano career. Survival. And then thirty years of refusing to let the experience be the whole story.
This keynote is not about inspiration. It is about what happens after you survive something the system was not built to handle, and what you build when you realize nobody is coming to fix it for you.
Audience Takeaway
Every person in the room leaves with a clearer understanding of what it actually costs to navigate a serious diagnosis alone, and why the difference between a patient who survives the system and one who does not is rarely clinical.
Best For
General healthcare conferences · Leadership summits · Patient advocacy organizations · Corporate keynotes · Any audience that needs the room to feel something before they will listen to anything else
The American Healthcare System Is Not Broken. It Was Built This Way.
The Talk
Drawing on We the Patients: Understanding, Navigating, and Surviving America’s Healthcare Nightmare (Wiley, 2026), Matthew traces the deliberate architecture of a system designed to extract profit rather than deliver care, from the 1971 White House tapes to the AI powered denial engines of 2026.
This is not a grievance talk, rather a diagnosis of a political success story that put patients at the bottom on purpose. And it comes with a prescription: the patient community is the largest unorganized missing political constituency in American history, and the moment it recognizes itself as a shared identity, everything changes.
Audience Takeaway
Leaders leave understanding the historical and political architecture behind the system’s most persistent failures, why fixing it requires organized patient power rather than better policy arguments, and what their organization’s role is in either accelerating or obstructing that change.
Best For
Health policy conferences · Employer benefits events · Life science and pharma leadership · Patient advocacy organizations · Any audience that needs the uncomfortable truth delivered with receipts
Nobody Cares What You Have to Say
The Talk
Healthcare organizations spend billions communicating with patients.
Almost none of it lands. Not because the message is wrong but because the medium is broken. Advertising works because it makes people feel something. Healthcare communication fails because it has decided that happy is not the point.
Matthew examines why institutional language, compliance shaped messaging, and empty empathy continue to erode trust, and what it actually takes to say something a patient will hear, believe, and act on.
Audience Takeaway
Communications and marketing leaders leave with a clear framework for why institutional language fails patients and what it takes to replace it with something a real person will actually hear, trust, and act on.
Best For
Healthcare marketing and communications teams · Patient engagement leaders · Life science and pharma commercial teams · Point of care marketing · Corporate affairs organizations
If You Build It, They Won’t Come
The Talk
The most sophisticated therapy in history means nothing if it never clears prior authorization, never survives the formulary, never reaches the patient who was diagnosed six months ago and has been fighting the system ever since. Matthew examines market access through the only lens that actually matters: the patient who is waiting. He connects the decisions made in conference rooms to the consequences lived in waiting rooms, and shows what changes when the patient experience becomes the organizing principle of access strategy rather than its afterthought.
Audience Takeaway
Market access and patient services leaders leave with an honest accounting of where access strategy loses the patient, what the experience of that failure actually looks like from the other side, and what changes when patient reality becomes the organizing principle of access design rather than its final consideration
Best For
Life science and pharma market access teams · Patient services and hub strategy leaders · HEOR and reimbursement teams · Any organization asking why their therapy is not reaching the patients it was designed for
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